Even when pregnancy is a common event in female reproductive life, little attention has received the perceived changes in the physical and psychological domain of women's health status and quality of life. The objective of this study was to evaluate the quality of life and coping strategies of pregnant mothers of high and habitual risk during the second and third trimesters of pregnancy, in the municipality of Dourados, Mato Grosso del Sur. 79 pregnant women, being 32 high risk and 47 habitual risk, the average age was 24.6 years; to whom a quality of life questionnaire and a coping questionnaire were applied. High-riskpregnant women have a better quality of life in the Health/Functioning and Family domains; likewise, in all the coping significant factors, These results demonstrate the need to accompany participants in special programs that are included in the prenatal period in order to contribute to coping with pregnancy.