This text presents a review of the psycho-emotional effects of social isolation. Its objective is to reflect on this measure taken in the pandemic, focusing on the psychological consequences. On the one hand, from official speeches, critical glances and mental health research. On the other hand, a study on the subject is carried out in Mexico where opinions, practices and the cognitive, emotional, behavioral and relational impacts are addressed. This is done through bibliographic and documentary review, as well as surveys, questionnaires and interviews, for the country and for Mexico City. As a result, the consideration between benefits and risks in general is presented. In particular, and in the case studied, a favorable assessment from the population, a relative follow-up, an accumulation of unpleasant feelings, psychological disorders, as well as changes in habits, activities and relationships.