Canine Histoplasmosis is an American important disease mostly in the central and southwest partof the United States that has not been yet reported in Colombia. Reports in human beings suggest the presence of this parasite in Colombia. This paperintends to report a case of canine histoplasmosis which was presented to the Small Animal Hospitalof La Salle University located at Bogotá- Colombia.The dog showed clinical signs of ataxia, turning, meningoecephalitis, the CSF analysis showed yeast-likeof Histoplasma capsulatum. For our information this is one of the first reports of meningo encephalitis by Histoplasma in dogs in Colombia.