Abstract Introduction: Prone position (PP) is a therapeutic alternative widely used and recommended in patients with COVID-19. Although PP is a non-invasive procedure, it is complex and could be associated with complications such as the development of pressure ulcers (PU). We aimed to propose a standardized nursing care plan in terms of NANDA-International, NIC (Nursing Interventions Classification) and NOC (Nursing Outcomes Classification) to prevent PU secondary to the PP in people with COVID-19. Content synthesis: In patients with COVID-19, in addition to risk factors such as advanced age and the presence of comorbidities, PP contributes to the presence of pressure ulcer risk nursing diagnoses [00249], of deterioration of skin [00047] and tissue [00248] integrity. On the other hand, the nursing intervention for the prevention of pressure ulcers [3540], due to the specificity and scientific basis of its activities, is key to minimize the development of this complication, improve the quality of care and the prognosis in this type of patients. Finally, to evaluate the effectiveness of nursing care, we propose the nursing results (NOC): consequences of immobility: physiological [0204] and tissue integrity: skin and mucous membranes [1101]. Conclusion: PP is a recommended adjunctive therapy for the management of critically ill COVID-19 patients due to its benefits to improve lung function. However, it is associated with adverse effects such as PU. This article presents recommendations based on a narrative review for a better implementation of preventive nursing care that reduces the frequency of PU in this population. How to cite this article: Rojas LZ, Mora Rico LA, Acosta Barón JV, Cristancho Zambrano LY, Valencia Barón YD, Hernández Vargas JA. Plan de cuidados de enfermería para la prevención de úlceras por presión secundarias a la posición prono en pacientes COVID-19. Revista Cuidarte. 2021;12(3):e2234. http://dx.doi.org/10.15649/cuidarte.2234