The methodology proposed by Tellez & L´opez-R´ıos (2013) for increasing the number of support points in a design is implemented in a D-optimal Bayesian design by two-compartment models. Data presented on Fresen(1986) are considered, referenced on Atkinson et al. (2007), where they modeled the ratio between Theophylline inoculated into the blood of a pony and the reaction time of the drug from a two-compartment model. The analytical results obtained in the paper previously validated and good behavior of the method is shown in terms of power and efficiency when compared to other designs available in the literature.