The present article offers a literary review and description of the educational mediation notions and their relationship with the Bio-pedagogy features in education. This description is specifically oriented to the crucial changes in education that have also affected the TEFL practices. In a nutshell, the purpose here is not to portray a teacher’s model but to be concerned about some features that would encourage the teaching experience with pedagogical mediations. The bibliographic search method was performed through the ERIC, SCIELO, SAGE, and Editorial Magisterio databases. The exploration was developed under the following stages: familiarization with the content of the documents, preliminary classification, selection and extraction of the most relevant information, verification of the concepts, and synthesis of the information. Pedagogical mediation occurs here when apprentices’ emotions and identities become the main pretext to mediate meaningful learning activities attending their second language needs. Finally, this article presents a personal concern about pedagogical mediation in my mediation experience.