The following theoretical revision aim was to study the impact of the psycho-social variables on the quality of life in people with chronic diseases. The health concept is considered as a behavior associated in the style of life. Quality of life concept and its main multidimentional aspects are defined, and the importance of the quality of life evaluation in chronic patients is justified. Additionally, some researches which evaluate the importance than psychological and social variables plays in the maintenance, recovery or loss of the health in five different chronic diseases: infarct, diabetes, cancer, AIDS and renal insufficiency, have been summarized. Key words: psycho-social aspects, quality of life, chronic diseases.