Objetive Assess left atrial (LA) contractile function in patients with paroxysmal (AF) using strain echocardiography before and after pulmonary vein isolation (PVI) and compare them with matched controls. Methods A prospective cohort study was conducted at the National Institute of Cardiology Ignacio Chavez from May 2021 to November 2022. Patients with paroxysmal AF underwent transthoracic echocardiography (TTE) assessing LA global strain and strain in the LA reservoir, conduit, and contraction phases strains before and after PVI. Echocardiographic parameters were compared prior to and after PVI, and against matched controls. Results 15 subjects with paroxysmal AF and 15 matched controls were analyzed. Post-PVI, subjects showed significant improvements in LA global and reservoir phase strains. Compared to controls, significant echocardiographic differences were noted pre-PVI, but not post-PVI. Conclusion PVI may enhance LA strain parameters in paroxysmal AF patients, aligning them with matched controls. This suggests PVI's potential restorative effect on atrial function. Further research is warranted to validate these observations.