Contextualization: The increase in wheat production has caused pathogenic diseases to appear more frequently due to the implementation of monoculture. The Septoriosis or stain of the wheat leaf caused by Zymoseptoria tritici causes a decrease in the photosynthetic area causing losses in grain yield ranging between 17% and 50%, depending on the phenological state in which the infection occurs.   Knowledge gap: The most frequent method for controlling the disease is the application of chemical synthesis products, which has generated resistance in the population of the fungus and contamination of the agroecosystems. For this reason, new management alternatives are being sought, such as the activation of systemic resistance. Induced by the application of salicylic acid that causes physical, chemical and molecular changes such as lignification or the induction of various proteins related to pathogenesis that does not allow the entry of the hyphae of pathogenic fungi, being a sustainable alternative.   Purpose: The purpose of this research was the evaluation of the effect of salicylic acid on the development of the symptoms of wheat leaf spot caused by Zymoseptoria tritici, and to establish its probable changes on the yield components in cultivars Biointa 3004 and Buck sy 200.   Methodology: The study was carried out at the Julio Hirschhorn experimental station of the National University of La Plata (UNLP), for which the cultivars Biointa 3004 and Buck sy 200 were used, the experimental design was in divided plots with three replications and was constituted by the following treatments: Control, inoculated with Zymoseptoria tritici, treated with salicylic acid and treated with salicylic acid and inoculated with Zymoseptoria tritici. and the tests were carried out in the winter-spring season of 2012 and 2013 and the percentage of pycnidia, the percentage of necrotic area, the number of empty spikelets, the number of grains of the spike, and the weight of 1000 grains were determined.   Results and conclusions: The pycnidia coverage decreased by 45%; the necrotic area, by 40%; in addition, the number of empty spikelets decreased by 4% and the number of grains per spike increased (5%) and the weight of 1000 grains (2%). It is shown that salicylic acid greatly controls the negative effects of the disease and stimulates the yield components, improving the productivity of two cultivars evaluated.