The objective of this study was to design and determine the face and content validity of an instrument for measuring the Social Determinants of Health. A quantitative instrumental methodological study, the design focused on the construction and validation of instruments. The process was structured in 4 phases through documentary review and the Delphi Technique with the participation of 14 experts. The instrument was structured in 7 general dimensions, 30 specific ones for the assessment of 19 structural determinants and 61 intermediate ones; it presented an internal consistency index according to Cronbach's Alpha coefficient of 0.952 and content validation according to Lawshe of 0.909. In conclusion, it provides an instrument designed and validated for the measurement of the Social Determinants of Health and can be applied in different fields and areas of expertise, levels and nationalities, and it is also the basis for future research processes.