This paper showcases the use of several discourses from the human and social sciences in the context of its thematic “Inequitable Impact in the Enforcement of Human Rights due to COVID-19 in Mexico”. Society today faces economic and health crisis scenarios; the authors reflect on how the basic elements of its dynamics have been affected. Additionally, the relevance of complying with human rights in the current context is emphasized; this is a priority in terms of civility and equality. This paper has a critic perspective while being constructive and feasible.