Introduction: Spirituality is a vital component of being human. It is established that enhancing the meaning and purpose of life influences people's well-being and quality of life. Objective: To evaluate the effectiveness of an educational program to promote spiritual growth in informal caregivers of people with disabilities in the Pamplona Region. Methodology: Quasi-experimental study that had a descriptive phase in which the HPLP-II instrument was applied to a sample of 308 informal caregivers. Based on the results, the thirty-nine most affected caregivers were identified, twenty being assigned to the control group and nineteen to the intervention group. Subsequently, a protocol of interventions was designed, which were evaluated at the end of the study. Results: In the descriptive phase it was found that 87.7% of the caregivers were in the category “they sometimes carry out practices that promote spiritual growth” and 12.66% do not conduct healthy practices. In the intervention phase it was found that when descriptively analyzing the differences in means with the Student T test, statistically significant results were found in the post-intervention and the experimental group when compared with the control group. Conclusion: When evaluating the educational intervention program, better performance in spiritual practices was found in caregivers after the interventions developed.