This article presents the results of a research project that proposes a methodology for integrating the occupational health and safety management system (OHSMS) into the quality management system (QMS) in Colombian public entities of national level. The foregoing, given the compulsory nature of its implementation established in Decree 1072 of 2015 for all public and private employers and Law 872 of 2003 establishes the QMS in the agencies and entities for services of the Executive Branch of the Public Power of the National level, among other. The research was developed in four stages: review of the literature identifying tools, strategies and theoretical references of integration and validation; correspondence analysis of the integrable requirements; preparation of the structured methodological proposal based on the ILOOSH-2001 guidelines and the validation of the content of the proposal with experts. In accordance with the above, this methodology becomes a guiding tool that provides benefits in institutional management such as integrated controls, improvement in service provision, reduction of work interruptions, prevention of over costs and administrative penalties.