The purpose of this research was to analyze the agility levels and its possible associations with independent health-related variables in students from Cáceres in Spain. A total of 360 students of both genders, aged between 11 and 16 years, living in the municipality of Cáceres, Spain, participated in the study. The Shuttle Run test was used to assess the motor component of agility in seconds, classified into five categories (excellent, good, fair, poor or very poor). The data were analyzed using the IBM SPSS Statistics 27.0.1 software. The results showed that the majority (80.9%) of the students had low agility levels, along with high levels of overall obesity and sedentary behavior. Abdominal obesity showed no association with agility levels in this study. It is expected that the findings can provide new insights/reflections on the health impacts associated with low agility levels.